Acta Epileptologica is the official journal of the China Association Against Epilepsy.
Articles
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Citation: Acta Epileptologica 2023 5:9
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Genetic mechanisms in generalized epilepsies
The genetic generalized epilepsies (GGEs) have been proved to generate from genetic impact by twin studies and family studies. The genetic mechanisms of generalized epilepsies are always updating over time. Al...
Citation: Acta Epileptologica 2023 5:8 -
Detection method of absence seizures based on Resnet and bidirectional GRU
Epilepsy is a common chronic neurological disease. Its repeated seizure attacks have a great negative impact on patients’ physical and mental health. The diagnosis of epilepsy mainly depends on electroencephal...
Citation: Acta Epileptologica 2023 5:7 -
Novel variants of SYNGAP1 associated epileptic encephalopathy: two cases report and literature review
SYNGAP1 is a significant genetic risk factor for global developmental delay, autism spectrum disorder, and epileptic encephalopathy. De novo loss-of-function variants in this gene cause a neurodevelopmental disor...
Citation: Acta Epileptologica 2023 5:6 -
Assessing structural integrity of the pyramidal tracts with diffusion spectrum imaging to predict postoperative motor function in pediatric epilepsy patients with hemispherectomy
Hemispherectomy is an effective treatment option for patients with drug-resistant epilepsy caused by hemispheric lesions. However, patients often have deterioration of their motor functions postoperatively. Di...
Citation: Acta Epileptologica 2023 5:2 -
A case of migraine misdiagnosed as epilepsy
Migraine and epilepsy are both episodic disorders, with some overlapping symptoms, mechanisms and therapies. Clinically, there is a comorbid relationship between them. Some migraine patients may exhibit epilep...
Citation: Acta Epileptologica 2023 5:3 -
Evaluation of P-glycoprotein-targeting circulating microRNAs as peripheral biomarkers for medically intractable epilepsy
Early diagnosis of medically intractable epilepsy is challenging in clinical work. P-glycoprotein (P-gp) is one of the most important multidrug efflux transporters, which has been demonstrated to contribute to...
Citation: Acta Epileptologica 2023 5:5 -
Reflex seizures induced by micturition: a case report
Reflex seizures (RS) induced by micturition are extremely rare, and the clinical and electroencephalogram features of RS are not widely known among clinicians. In particular, the origin of the epileptic area i...
Citation: Acta Epileptologica 2023 5:4 -
The effect of hippocampal NR2B-containing NMDA receptors on chronic cognitive dysfunction in rats with temporal lobe epilepsy
We have previously reported that hippocampal long-term potentiation (LTP) was suppressed in temporal lobe epilepsy (TLE) rats. The N-methyl-D-aspartic acid receptors containing 2B subunit (NR2B-NMDARs) are ind...
Citation: Acta Epileptologica 2023 5:1 -
Development of localized interictal epileptiform discharges following vagus nerve stimulation for lennox-gastaut syndrome: a case report
Lennox-gastaut syndrome (LGS) is an epileptic encephalopathy often associated with behavioral and psychiatric disorders. Vagus nerve stimulation (VNS) has been approved effective for LGS treatment. Surgical re...
Citation: Acta Epileptologica 2022 4:40 -
Two cases of childhood absence epilepsy who showed seizure disappearance after ethosuximide drug eruption
Recent studies suggest potential roles of immune response in the pathophysiology of epilepsy. Anti-seizure medications (ASMs) are known to have side effects of drug eruption caused by immune responses. A few r...
Citation: Acta Epileptologica 2022 4:36 -
Long-term follow-up of vagus nerve stimulation in drug-resistant KCNT1-related epilepsy: a case presentation
The KCNT1 gene encodes a Na+-activated K+ channel. Gain-of-function mutations of KCNT1 lead to autosomal dominant sleep-related hypermotor epilepsy, early-onset epileptic encephalopathy, focal epilepsy and other ...
Citation: Acta Epileptologica 2022 4:34 -
Case report of antiseizure medicine-induced long QT syndrome and a literature review
To realize the clinical characteristics of long QT syndrome (LQTS) caused by antiseizure medicines (ASMs), and to improve the prevention and management of ASM-acquired QT syndrome.
Citation: Acta Epileptologica 2022 4:39 -
Potentials of miR-9-5p in promoting epileptic seizure and improving survival of glioma patients
Epilepsy affects over 70 million people worldwide; however, the underlying mechanisms remain unclear. MicroRNAs (miRNAs) have essential functions in epilepsy. miRNA-9, a brain-specific/enriched miRNA, plays a ...
Citation: Acta Epileptologica 2022 4:33 -
Synchronization clusters located on epileptic onset zones in neocortical epilepsy
Brain function is thought to rely on complex interactions of dynamic neural systems, which depend on the integrity of structural and functional networks. Focal epilepsy is considered to result from excessive f...
Citation: Acta Epileptologica 2022 4:42 -
Anti-NMDAR encephalitis with seizure-like activity and hemiplegia - a case report and literature review
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis accounts for the vast majority of cases of autoimmune encephalitis. Its common clinical symptoms are psychiatric symptoms, behavioral dysfunction, seizures,...
Citation: Acta Epileptologica 2022 4:30 -
The influence of genetics on epilepsy syndromes in infancy and childhood
Genetics is rapidly evolving and is actively playing a role in how we diagnose and manage epilepsy. The definition of an epilepsy syndrome has changed throughout the years. The International League Against Epi...
Citation: Acta Epileptologica 2022 4:41 -
Posterior quadrant epilepsy surgery: case series of a South American hospital
Posterior quadrant epilepsy (PCE) is a type of focal epilepsy that originates in the parietal lobe, occipital lobe, and the parietal-occipital border of the temporal lobe, or in any combination of these region...
Citation: Acta Epileptologica 2022 4:27 -
Ganglioglioma surgery associated with postoperative status epilepticus: a case report
Gangliogliomas are brain tumors associated with drug-resistant focal epilepsy. In most cases, seizures improve after surgical treatment. It is still not concluded to what extent the lesion itself or the perile...
Citation: Acta Epileptologica 2022 4:26 -
Long-term outcomes and prognosis factors of vagus nerve stimulation in patients with refractory epilepsy
Vagus nerve stimulation (VNS) is an effective treatment for patients with refractory epilepsy, yet with varied predictive factors and heterogeneous long-term outcomes. Adjustment of VNS parameters is critical ...
Citation: Acta Epileptologica 2022 4:38 -
Utilization of quantitative electroencephalogram in China: an online questionnaire survey
Quantitative electroencephalogram (QEEG) is a tool that uses a computer to analyze brain activity monitored by electroencephalogram (EEG) according to measurements such as frequency, amplitude, and slope. The ...
Citation: Acta Epileptologica 2022 4:37 -
A case of Dravet syndrome with focal cortical myoclonus
Dravet syndrome (DS) is a severe epileptic encephalopathy in children dominated by polymorphic seizures. Focal cortical myoclonus indicated on conventional electroencephalogram (EEG) was rarely observed in DS.
Citation: Acta Epileptologica 2022 4:13 -
The interaction between circadian rhythm and epilepsy
Evidence about the interaction between circadian rhythms (CR) and epilepsy has been expanded with the application of advanced detection technology. An adequate understanding of how circadian system and epileps...
Citation: Acta Epileptologica 2022 4:28 -
Altered brain activity in juvenile myoclonic epilepsy with a monotherapy: a resting-state fMRI study
Juvenile myoclonic epilepsy (JME) is the most common syndrome of idiopathic generalized epilepsy. Although resting-state functional magnetic resonance imaging (rs-fMRI) studies have found thalamocortical circu...
Citation: Acta Epileptologica 2022 4:29 -
Neuromodulation for temporal lobe epilepsy: a scoping review
Temporal lobe epilepsy (TLE) is difficult to treat as it is often refractory to treatment. Apart from traditional medical treatment, surgical resection is also a choice of treatment, but it may be associated w...
Citation: Acta Epileptologica 2022 4:25 -
Surgical treatment of pediatric intractable frontal lobe epilepsy due to malformation of cortical development
Malformation of cortical development (MCD) is a common cause of intractable epilepsy in children. In this study, the effectiveness of frontal lobe epilepsy (FLE) surgery in children with intractable epilepsy d...
Citation: Acta Epileptologica 2022 4:23 -
Reactive glia-to-GABAergic neuron reprogramming: a “golden touch” strategy to alleviate intractable seizures
This commentary highlights a research article published recently in Cell Stem Cell “Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy...
Citation: Acta Epileptologica 2022 4:35 -
Calculation and management of ketogenic diet parenteral nutrition in super-refractory status epilepticus
Super-refractory status epilepticus (SRSE) is an important neurological emergency associated with high mortality and morbidity and poses a heavy economic burden on patients. Ketogenic diet parenteral nutrition...
Citation: Acta Epileptologica 2022 4:32 -
miRNA-let-7i modulates status epilepticus via the TLR4 pathway
Status epilepticus (SE) is a neurological emergency associated with high mortality and morbidity. Many SE episodes cannot be quickly and effectively terminated with current medications. miRNA-Let-7i, a member ...
Citation: Acta Epileptologica 2022 4:20 -
Blood and CSF biomarkers for post-stroke epilepsy: a systematic review
Post-stroke epilepsy is a common complication of ischemic stroke which adversely affects the prognosis of patients. Clinical and radiological parameters cannot adequately predict the risk. Therefore, the disco...
Citation: Acta Epileptologica 2022 4:21 -
Social support for and features of Chinese adults with epilepsy
The lack of social support for adults with epilepsy (AWEs) is receiving increased attention, as it may result in low quality of life. This study was aimed to confirm the demographic characteristics of and clin...
Citation: Acta Epileptologica 2022 4:18 -
Gene variations of glutamate metabolism pathway and epilepsy
Epilepsy is a paroxysmal disorder of the brain, caused by an imbalance of neuronal excitation and inhibition. Glutamate is the most important excitatory neurotransmitter in the brain and plays an important rol...
Citation: Acta Epileptologica 2022 4:31 -
Toward social neuropsychology of epilepsy: a meta-analysis on social cognition in epilepsy phenotypes and a critical narrative review on assessment methods
The aim of this review is to (a) characterize social cognition impairments in the domains of emotion recognition (ER) and theory of mind (ToM) in patients with epilepsy and (b) to review assessment tools with ...
Citation: Acta Epileptologica 2022 4:24 -
Withdrawal seizures vs on-medication seizures: an intracranial EEG recording case report
It has long been an interesting question of whether withdrawal seizures in epileptic patients differ from habitual seizures in terms of semiology and electrophysiology.
Citation: Acta Epileptologica 2022 4:17 -
Human herpesvirus 6B infection in mesial temporal lobe epilepsy: a meta-analysis
Whether human herpesvirus 6B (HHV-6B) can affect mesial temporal lobe epilepsy (MTLE) remains controversial. The present meta-analysis was aimed to evaluate whether HHV-6B is significantly associated with MTLE.
Citation: Acta Epileptologica 2022 4:19 -
Long non-coding RNA Tug1 regulates inflammation in microglia and in status epilepticus rats through the NF-κB signaling pathway
Inflammation plays an important role in the pathogenesis of status epilepticus (SE). The long non-coding RNA (lncRNA) taurine up-regulated gene1 (Tug1) plays a well-defined role in inflammatory diseases. Howev...
Citation: Acta Epileptologica 2022 4:9 -
Anxiety and depression among epilepsy patients in low-risk areas for COVID-19 in the northern part of Guizhou Province, China, during the COVID-19 pandemic
This study was aimed to investigate whether patients with epilepsy (PWE) have higher depression and anxiety levels than the normal population in low-risk areas for coronavirus disease 2019 (COVID-19) in the no...
Citation: Acta Epileptologica 2022 4:22 -
Gender differences in prevalence and risk factors of sleep disturbances in patients with epilepsy
Sleep disturbances are frequently observed in patients with epilepsy (PWE), with adversely effects on life quality and seizure control. The study aimed to assess the gender differences in incidence and factors...
Citation: Acta Epileptologica 2022 4:7 -
Ketogenic dietary therapy in adult status epilepticus: current progress and clinical application
Status epilepticus (SE) is a common fatal neurological disease with high morbidity and mortality. Even if a large proportion of patients might be relieved from anti-seizure medications, sedatives and anestheti...
Citation: Acta Epileptologica 2022 4:16 -
Two cases of anesthetics-induced epileptic seizures: a case report and literature review
Anesthetics like propofol have been reported to be capable of controlling status epilepticus. However, we have observed during daily clinical work that some anesthetics can induce epileptic seizures. Therefore...
Citation: Acta Epileptologica 2022 4:5 -
Analysis of electroclinical features of nonconvulsive status epilepticus: a study of four cases
The nonconvulsive status epilepticus (NCSE) is an epileptic condition characterized by little or no obvious symptoms, thus is often easily to be underrecognized, underdiagnosed or even undetected by clinicians...
Citation: Acta Epileptologica 2022 4:4 -
Ketogenic diet therapy for epilepsy: past 100 years of practice
Citation: Acta Epileptologica 2022 4:15 -
Correction to: A multicenter retrospective cohort study of ketogenic diet therapy in 481 children with infantile spasms
Citation: Acta Epileptologica 2022 4:14 -
Efficacy and tolerability of ketogenic diet therapy in 55 Chinese children with drug-resistant epilepsy in Northwest China
Due to the tradition of carbohydrate-rich diet, challenges exist for ketogenic diet (KD) implementation in Northwest China. This study was aimed to investigate the efficacy and tolerability of KD therapy admin...
Citation: Acta Epileptologica 2022 4:10 -
Successful medical treatment of west syndrome with a KCNA2 variant: a case report
West syndrome is a devastating disorder characterized by a triad of epileptic spasms, abnormal electroencephalography (EEG), and developmental arrest or psychomotor delay. In addition to early diagnosis, knowi...
Citation: Acta Epileptologica 2022 4:6 -
Chinese expert recommendations on ketogenic diet therapy for super-refractory status epilepticus
Super-refractory status epilepticus (SRSE) is a serious and life-threatening neurological condition. Ketogenic diet (KD) is a diet characterized by high fat, low carbohydrate, and moderate protein. As KD shows...
Citation: Acta Epileptologica 2022 4:8 -
A multicenter retrospective cohort study of ketogenic diet therapy in 481 children with infantile spasms
Ketogenic diet (KD) therapy is one of the main treatments for drug-resistant epilepsy. However, the KD therapy has been applied in only a small number of infantile spasm cases. In this large multicenter study,...
Citation: Acta Epileptologica 2022 4:11 -
Validation of an epilepsy management smartphone application in Pakistan
There is no single way to improve epilepsy care in low- and middle-income countries (LMICs). An epilepsy management aid application (app) has been described, which enables a non-physician health worker (NPHW) ...
Citation: Acta Epileptologica 2022 4:12 -
Knowledge and attitudes of driver license applicants and instructors about driving of patients with epilepsy in Burkina Faso
Epilepsy is the most common neurological disease in the world. The objective of the study was to determine the knowledge, attitude and practice of driver’s license applicants and instructors in driving schools...
Citation: Acta Epileptologica 2022 4:3 -
A case of Landau-Kleffner syndrome with SLC26A4-related hearing impairment
Landau-Kleffner syndrome (LKS) is an acquired aphasia and electroencephalogram (EEG) abnormalities mainly in temporoparietal areas. SLC26A4 mutations can cause hearing loss associated with enlarged vestibular aqu...
Citation: Acta Epileptologica 2022 4:1
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