Articles

The role of the TNFα-mediated astrocyte signaling pathway in epilepsy

Epilepsy is a common disease  in the central nervous system. There is growing evidence that epilepsy is associated with glial cells, including astrocytes. Tumor necrosis factor α (TNFα) is a “master regulator”...

Authors: Rui Chen, Guofang Xue and Christian Hölscher

Blood pressure, body mass index lowering and ketogenesis in Qigong Bigu

Hypertension is one of the most common comorbid conditions of epilepsy. Hypertension and epilepsy may be related to each other. Qigong Bigu practice induces a similar effect as fasting in the first week. As ke...

Authors: Bin Hong, Runqi Luo, Dezhi Cao, Man Zhang, Kewei Fang, Jianhong Guo and Jianxiang Liao

Psychogenic non-epileptic seizures (PNES) in the context of concurrent epilepsy – making the right diagnosis

Epilepsy is a risk factor for the development of psychogenic non-epileptic seizures (PNES) and comorbid epilepsy is recognized as a comorbidity in about 10–30% of patients with PNES. The combination of epilept...

Authors: Andreas Liampas, Sofia Markoula, Panagiotis Zis and Markus Reuber

The pharmacological treatment of epilepsy: recent advances and future perspectives

The pharmacological armamentarium against epilepsy has expanded considerably over the last three decades, and currently includes over 30 different antiseizure medications. Despite this large armamentarium, abo...

Authors: Emilio Perucca

Recent aspects of ketogenic diet in neurological disorders

The ketogenic diet (KD) is a high-fat, low-carbohydrate diet, in which fat is used as the primary energy source through the production of ketone bodies (KBs) in place of glucose. The KD was formally introduced...

Authors: Hye Eun Kwon and Heung Dong Kim

RHOBTB2 gene associated epilepsy and paroxysmal movement disorder: two cases report and literature review

RHOBTB2 gene is associated with developmental and epileptic encephalopathy-64(DEE-64), which is characterized by epilepsy, developmental delay, microcephaly, unspecific facial dysmorphism, and paroxysmal movement...

Authors: Xueyang Niu, Yan Sun, Ying Yang, Miaomiao Cheng, Quanzhen Tan, Jie Zhang and Yuehua Zhang

Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model

Epileptic seizure is a process of energy accumulation, bursting, and depletion accompanied by the production, spread, and termination of epileptic discharges. The energy required for a seizure is mainly provid...

Authors: Guohui Jiang, Shenglin Wang, Mingyue Chen, Xiaomi Ding, Weiwei He, Li Wang, Shunxian Wang, Juming Yu and Xiaoming Wang

Correction to: Early surgical intervention for structural infantile spasms in two patients under 6 months old: a case report

Authors: Haiyan Yang, Zhiquan Yang, Jing Peng, Yehong Huang, Zhuanyi Yang, Fei Yin and Liwen Wu

Seizure frequency and obstetric complications at advanced maternal age: a preliminary observational study in women with epilepsy

Seizure control during pregnancy and obstetric outcomes are of important concerns for women with epilepsy (WWE) and their families. Advanced maternal age (≥35 years) shows a growing trend in the society with c...

Authors: Hui Gao, Nanya Hao, Shanrui Liu and Dong Zhou

Practical considerations of dietary therapies for epilepsy in adults

Despite the increasing number of anti-seizure medications becoming available, the proportion of patients with drug-resistant epilepsy remains unchanged. Dietary therapy for epilepsy is well-established practic...

Authors: Neha Kaul, John-Paul Nicolo, Terence J. O’Brien and Patrick Kwan

Special issue on the battle against complex virus world in the human brain: seizure as a result of viral infection

Authors: Weijia Jiang, Jinmei Li, Dong Zhou and Jie Mu

Current advances on mechanisms and treatment of post-stroke seizures

Cerebrovascular diseases are among the most common causes of seizures in adults, especially in the elderly. With the increased incidence of stroke, the population with post-stroke seizures has grown, leading t...

Authors: Yujiao Fu, Li Feng and Bo Xiao

HMGB1, neuronal excitability and epilepsy

Epilepsy is a common neurological disease caused by synchronous firing of hyperexcitable neurons. Currently, anti-epileptic drugs remain the main choice to control seizure, but 30% of patients are resistant to...

Authors: Sijie Dai, Yang Zheng, Yi Wang and Zhong Chen

Correction to: Leucine-rich glioma-inactivated protein 1 antibody-mediated autoimmune encephalitis in a 4-year-old girl: a case report

Authors: Junxia Luo, Jianguo Shi, Yehong Chen, Wandong Hu, Yujie Guo, Guangshun Hou and Zaifen Gao

Functional hemispherectomy for patients with adult-onset Rasmussen’s encephalitis

Surgical treatment for patients with adult-onset Rasmussen’s encephalitis (A-RE) is rarely reported. We investigated the clinical and surgical features of two patients with A-RE who underwent functional hemisp...

Authors: Hong Xue, Cuiping Xu, Xiaoxia Zhou, Duanyu Ni, Xueyuan Wang and Tao Yu

Temporal lobe epilepsy associated with human herpes virus 6

Human herpes virus 6 (HHV-6) is a ubiquitous and most common pathogen that affects humans. Human herpes virus 6B (HHV-6B) is a wide spread human herpesvirus that infects most people when they are children, est...

Authors: Jiaqi Wang and Jinmei Li

Association between GABRG2 rs211037 polymorphism and idiopathic generalized epilepsies: a meta-analysis

We performed this meta-analysis to investigate the association between GABRG2 rs211037polymorphism and the risk for idiopathic generalized epilepsies (IGEs).

Authors: Xiaohui Yang, Hongyun Ding, Hongyun Wei, Jia Liu, Pingping Liao, Yuzhu Zhang, Xiaomeng Wang and Xiaosa Chi

Three cases of paroxysmal alien limb phenomena due to epileptic seizures and review of literatures

The alien hand phenomenon (AHP) is a rare disorder of involuntary limb movement together with a loss of sense of limb ownership. AHP occurs as a consequence of frontal, callosal, or posterior cerebral lesions....

Authors: Weiwei Wang, Yang Liu, Hao Yu, Qingzhu Liu, Shuang Wang, Xiaoyan Liu, Lixin Cai and Xun Wu

PRRT2 gene and protein in human: characteristics, evolution and function

This study was designed to characterize human PRRT2 gene and protein, in order to provide theoretical reference for research on regulation of PRRT2 expression and its involvement in the pathogenesis of paroxysmal...

Authors: Yinchao Li, Shuda Chen, Chengzhe Wang, Peiling Wang, Xi Li and Liemin Zhou

The role of picornavirus infection in epileptogenesis

Picornaviridae are a family of small positive-strand RNA viruses, and transmitted via the respiratory or fecal-oral route. The neurotropic picornaviruses can induce acute or late recurrent seizures following cent...

Authors: Runxuan Zhang, Jie Mu, Jing Chi, Weijia Jiang and Xiaosa Chi

Association between GABRG2 rs211037 polymorphism and febrile seizures: a meta-analysis

Emerging evidence has implied that the GABRG2 gene play a role in the mechanism of febrile seizure (FS), however, the relationship between GABRG2 rs211037 polymorphism and the risk of FS remains controversial. Th...

Authors: Xiaohui Yang, Jing Chi, Xiaomeng Wang, Hongyun Wei, Xueping Zheng, Yi Hu, Song Hu, Yongjun Mao and Xiaosa Chi

Leucine-rich glioma-inactivated protein 1 antibody-mediated autoimmune encephalitis in a 4-year-old girl: a case report

Leucine-rich glioma-inactivated protein 1 (LGI1) antibody-mediated encephalitis is a rare subtype of autoimmune encephalopathy, which is associated with autoimmunity against the neuronal plasma membrane protei...

Authors: Junxia Luo, Jianguo Shi, Yehong Chen, Wandong Hu, Yujie Guo, Guangshun Hou and Zaifen Gao

Dynamic structural neuroplasticity during and after epileptogenesis in a pilocarpine rat model of epilepsy

The role of neuroplasticity in epilepsy has been widely studied in experimental models and human brain samples. However, the results are contradictory and it remains unclear if neuroplasticity is more related ...

Authors: Soomaayeh Heysieattalab and Leila Sadeghi

Involvement of GluA1-AMPAR-mediated LTP in time-dependent decline of cognitive function in rats with temporal lobe epilepsy

Cognitive impairment is one of the common comorbidities in patients with temporal lobe epilepsy (TLE), but the underlying mechanisms remain largely unknown. Previous studies have found significant decay of hip...

Authors: Xiaoqing Luo, Xiaoli Yu, Jufang Liang, Ruidi Sun, Cheng Li and Jun Jiang

Models for predicting treatment efficacy of antiepileptic drugs and prognosis of treatment withdrawal in epilepsy patients

Although antiepileptic drugs (AEDs) are the most effective treatment for epilepsy, 30–40% of patients with epilepsy would develop drug-refractory epilepsy. An accurate, preliminary prediction of the efficacy o...

Authors: Shijun Yang, Bin Wang and Xiong Han

Clinical characteristics of brain tumor-related epilepsy and factors influencing the identification of epilepsy-associated tumors

To analyze the clinical features of brain tumor-related epilepsy (BTRE) and explore the factors influencing the identification of epilepsy-associated tumor (EAT), in order to advance the clinical understanding...

Authors: Xianwen Zhang, Liaoyuan Zheng, Jingfeng Duan, Zongping Li and Yufeng Tang

Research progress on the prediction of post-stroke epilepsy

Epilepsy is a common neurological disease that not only causes difficulties in the work and life activities of patients, but also brings complex social problems. Cerebrovascular disease is currently the main c...

Authors: Shangnan Zou and Yangmei Chen

Sudden unexpected death after acute symptomatic seizures in a patient on mechanical ventilation

The mechanism of sudden unexpected death in epilepsy remains poorly understood. Seizure induced cardiac arrhythmia, central and obstructive apneas have been proposed as possible causes of death. Here we report...

Authors: Raisa C. Martinez, Naoum P. Issa, Shasha Wu, Xi Liu, Sandra Rose and James X. Tao

Correction to: Arbovirus and seizures

An amendment to this paper has been published and can be accessed via the original article.

Authors: Mingrui Zheng, Shichuo Li, R. Edward Hogan and Meihua Yang

Bilateral asymmetric tonic seizure in insulo-opercular epilepsy: an anatomo-electro-clinical study

Insulo-opercular seizures are highly heterogeneous in seizure semiology and electrical features. Bilateral asymmetric limb posturing, as a classical pattern of supplementary sensorimotor area (SMA) seizure, al...

Authors: Xiangshu Hu, Kaihui Li, Xiao Wang, Ping Yang, Qinghua Tan, Danfang Li, Xiaobo Wang, Fang Zeng, Yang Jin, Lingxia Fei, Hua Li, Junxi Chen and Qiang Guo

Effects of febrile seizures in mesial temporal lobe epilepsy with hippocampal sclerosis on gene expression using bioinformatical analysis

To investigate the effect of long-term febrile convulsions on gene expression in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) and explore the molecular mechanism of MTLE-HS.

Authors: Yinchao Li, Chengzhe Wang, Peiling Wang, Xi Li and Liemin Zhou

Arbovirus and seizures

The high prevalence and spread of arthropod-borne viruses (arboviruses) make them an important cause of viral encephalitis in humans. Most epidemic viral encephalitides have an etiology associated with arbovir...

Authors: Mingrui Zheng, Shichuo Li, R. Edward Hogan and Meihua Yang

Management of people with epilepsy during the COVID-19 pandemic: a national survey among epileptologists in China

Compared to the healthy people, people with comorbid medical conditions are more vulnerable in the context of the coronavirus disease 2019 (COVID-19) pandemic, including the people with epilepsy. Besides a con...

Authors: Zhenxu Xiao, Ding Ding, Shichuo Li and Zhen Hong

Current epidemiological and etiological characteristics and treatment of seizures or epilepsy in patients with HIV infection

Seizures or epilepsy is one of the common serious complications in patients with advanced human immunodeficiency virus (HIV) infection or diagnosed with immune deficiency syndrome, with higher incidence and pr...

Authors: Changhao Yu, Dong Zhou, Weijia Jiang and Jie Mu

Early surgical intervention for structural infantile spasms in two patients under 6 months old: a case report

Infantile spasms (IS) are the most common childhood epileptic encephalopathy. Focal cortical dysplasia (FCD) and gray matter heterotopias (GH) are common structural causes of IS. The recommended first-line tre...

Authors: Haiyan Yang, Zhiquan Yang, Jing Peng, Yehong Huang, Zhuanyi Yang, Fei Yin and Liwen Wu

The role of inflammation in epileptogenesis

Epilepsy is a chronic neurological disorder that has an extensive impact on a patient’s life. Accumulating evidence has suggested that inflammation participates in the progression of spontaneous and recurrent ...

Authors: Fanwei Meng and Lifen Yao

Clinical phenotype features and genetic etiologies of 38 children with progressive myoclonic epilepsy

Progressive myoclonic epilepsy (PME) is a group of neurodegenerative diseases with genetic heterogeneity and phenotypic similarities, and many cases remain unknown of the genetic causes. This study is aim to s...

Authors: Jing Zhang, Ying Yang, Xueyang Niu, Jiaoyang Chen, Wei Sun, Changhong Ding, Lifang Dai, Liping Zhang, Qi Zeng, Yi Chen, Xiaojuan Tian, Xiaoling Yang, Taoyun Ji, Zhixian Yang, Yanling Yang, Yuwu Jiang…

Ictal-interictal continuum: a review of recent advancements

Continuous electroencephalogram (cEEG) has become an indispensable technique in the management of critically ill patients for early detection and treatment of non-convulsive seizures (NCS) and non-convulsive s...

Authors: James X. Tao, Xiaoxiao Qin and Qun Wang

Seizures and epilepsy secondary to viral infection in the central nervous system

Viral infection in the central nervous system (CNS) is a common cause of seizures and epilepsy. Acute symptomatic seizures can occur in the context of almost all types of acute CNS viral infection. However, la...

Authors: Peng Zhang, Yuting Yang, Jialin Zou, Xinrui Yang, Qiankun Liu and Yangmei Chen

Interictal and Ictal MEG in presurgical evaluation for epilepsy surgery

Although presurgical evaluation of patients with pharamacoresistent focal epilepsies provides essential information for successful epilepsy surgery, there is still a need for further improvement. Developments ...

Authors: Hermann Stefan and Stefan Rampp

Continuous video electroencephalogram for herpes simplex encephalitis: a case report and literature review

Electroencephalogram (EEG) is an important tool for the diagnosis of herpes simplex virus encephalitis (HSE). However, the diagnosis of non-convulsive status epilepticus (NCSE) in HSE is challenging without th...

Authors: Wanhui Lin, Shenggen Chen, Hanbin Lin, Changyun Liu and Huapin Huang

Electromagnetic activity: a possible player in epilepsy

Epilepsy is a common disease with frequent occurrences. Many precipitating factors contribute to epileptic seizures, such as hyperventilation and alcohol consumption. An increasing number of studies have also ...

Authors: Yi Guo, Yaowen Liu and Xuefeng Wang

Expert consensus on clinical applications of high-frequency oscillations in epilepsy

Studies in animal models of epilepsy and pre-surgical patients have unanimously found a strong correlation between high-frequency oscillations (HFOs, > 80 Hz) and the epileptogenic zone, suggesting that HFOs c...

Authors: Yuping Wang, Dong Zhou, Xiaofeng Yang, Xin Xu, Liankun Ren, Tao Yu, Wenjing Zhou, Xiaoqiu Shao, Zhixian Yang, Shuang Wang, Dezhi Cao, Chunyan Liu, Shang Yeong Kwan and Jing Xiang

The first-line management of psychogenic non-epileptic seizures (PNES) in adults in the emergency: a practical approach

Distinguishing non-epileptic events, especially psychogenic non-epileptic seizures (PNES), from epileptic seizures (ES) constitutes a diagnostic challenge. Misdiagnoses are frequent, especially when video-EEG ...

Authors: Dènahin Hinnoutondji Toffa, Laurence Poirier and Dang Khoa Nguyen

Epilepsy control during an epidemic: emerging approaches and a new management framework

Epidemics are a big threat to world health. The ongoing pandemic of corona virus disease 2019 (COVID-19) has caused a series of challenges to public health. One such challenge is the management of chronic dise...

Authors: Deng Chen, Lina Zhu, Xin Lin, Zhen Hong, Shichuo Li, Ling Liu and Dong Zhou

Machine learning applications for electroencephalograph signals in epilepsy: a quick review

Machine learning (ML) is a fundamental concept in the field of state-of-the-art artificial intelligence (AI). Over the past two decades, it has evolved rapidly and been employed wildly in many fields. In medic...

Authors: Yang Si

The ketogenic diet for paediatric patients with super-refractory status epilepticus in febrile infection-related epilepsy syndrome

To investigate the effect and safety of ketogenic diet (KD) for the treatment of paediatric patients with super-refractory status epilepticus (SRSE) in febrile infection-related epilepsy syndrome (FIRES).

Authors: Xinhua Wang, Xuan Gao, Guoping Lu, Zhongying Lu, Shuizhen Zhou, Yi Wang and Yuanfeng Zhou

A case report of microcephaly and refractory West syndrome associated with WDR62 mutation

The autosomal recessive form of primary microcephaly (MCPH) is a rare disorder characterized by microcephaly with variable degree of intellectual disability. WDR62 has been reported as the second causative gene o...

Authors: Ping Zhou, Xin Ding, Qi Zeng, Huafang Zou, Jianxiang Liao and Dezhi Cao

The clinical phenotypes and genetic characteristics of seven epilepsy patients related to heterozygous DEPDC5 variants in China

DEPDC5 together with NPRL2 and NPRL3 forms the GATOR1 which plays an important role in the the mechanistic target of rapamycin (mTOR) pathway. Deregulation of mTOR signalling has been associated to various neu...

Authors: Zihan Wei, Luojun Wang, Xiaozhi Qiao, Ying Zhang, Chao Liu and Yanchun Deng

The prevalence, characteristics and outcome of seizure in tuberculous meningitis

Seizures are a common finding in patients with tuberculous meningitis (TBM), and associate with four times increased risk of death and neurological disability, especially in children. It has been reported that...

Authors: Ammar Taha Abdullah Abdulaziz, Jinmei Li and Dong Zhou