Skip to main content

Table 2 Comorbidities in elder patients with and without seizure-freedom

From: Clinical characteristics and impact of comorbidities on the prognosis of senile epilepsy in Southwest China: a retrospective cohort study

 

Seizure-freedom

Without seizure-freedom

χ2

v

P-value

crude OR

95% CI

P-value

adj. OR

95% CI

P-value

n

%

n

%

At least one comorbidity

51

40.8%

74

59.2%

4.306

1

0.038*

2.374

1.035–5.448

0.041*

2.104

0.880–5.032

0.094

Number of comorbidities

 0

18

62.1%

11

37.9%

5.748

3

0.125

1.405

1.054–1.872

0.020*

1.336

0.987–1.808

0.061

 1

17

48.6%

18

51.4%

 2

14

41.2%

20

58.8%

 ≥ 3

20

35.7%

36

64.3%

Comorbidity type

Neurological

35

37.2%

59

62.8%

5.591

1

0.018*

2.204

1.139–4.265

0.019*

1.705

0.844–3.443

0.137

 Traumatic brain injury

7

35.0%

13

65.0%

0.894

1

0.345

1.599

0.600–4.259

0.348

1.441

0.520–3.997

0.482

 Intracranial tumors

3

30.0%

7

70.0%

0.416

1

0.519

1.974

0491–7.940

0.338

1.913

0.434–8.443

0.392

 Dementia

10

38.5%

16

61.5%

0.509

1

0.476

1.368

0.577–3.243

0.477

1.379

0.558–3.410

0.487

 Parkinson's Disease

2

33.3%

4

66.7%

0.025

1

0.875

1.654

0.294–9.312

0.568

3.997

0.609–26.240

0.149

 Alcoholic encephalopathy

0

0.0%

4

100.0%

1.733

1

0.188

Ne

-

Ne

-

-

 Cerebrovascular disease

23

44.2%

29

55.8%

0.010

1

0.918

1.036

0.529–2.208

0.918

0.824

0.395–1.718

0.605

  Cerebral infarction

9

32.1%

19

67.9%

2.219

1

0.136

1.919

0.807–4.566

0.140

1.635

0.654–4.086

0.292

  Cerebral hemorrhage

9

56.3%

7

43.8%

0.946

1

0.331

0.598

0.211–1.699

0.335

0.404

0.123–1.324

0.135

  Cerebral vascular malformations

5

62.5%

3

37.5%

0.447

1

0.504

0.468

0.108–2.033

0.311

0.462

0.088–2.415

0.360

Psychiatric

10

25.0%

30

75.0%

8.571

1

0.003**

3.218

1.440–7.194

0.004**

2.606

1.124–6.041

0.026*

 Anxiety

8

25.8%

23

74.2%

5.665

1

0.017*

2.829

1.175–6.811

0.020*

2.665

1.067–6.654

0.036*

 Depression

8

25.0%

24

75.0%

6.407

1

0.016*

3.000

1.250–7.199

0.014*

2.469

0.989–6.165

0.053

 Psychotic disorders

0

0.0%

2

100.0%

Fisher’s exact test

0.502

Ne

-

-

Ne

-

-

Cardiovascular

32

46.4%

37

53.6%

0.125

1

0.724

0.891

0.471–1.688

0.724

0.913

0.461–1.809

0.794

 Hypertension

31

49.2%

32

50.8%

0.835

1

0.361

0.740

0.388–1.412

0.361

0.736

0.368–1.473

0.386

 Heart disease

7

33.3%

14

66.7%

1.294

1

0.255

1.746

0.663–4.603

0.259

1.677

0.602–4.670

0.322

Endocrine/metabolic

10

32.3%

21

67.7%

2.471

1

0.116

1.936

0.842–4.449

0.120

1.953

0.816–4.672

0.133

 Diabetes

6

26.1%

17

73.9%

3.831

1

0.050

2.625

0.974–7.077

0.057

2.516

0.890–7.114

0.082

 Osteoporosis

5

55.6%

4

44.4%

0.104

1

0.504

0.632

0.163–2.451

0.507

0.767

0.190–3.103

0.710

Respiratory

2

33.3%

4

66.7%

0.025

1

0.875

1.654

0.294–9.312

0.568

1.759

0.279–11.080

0.547

Neoplasms (Extracranial)

2

40.0%

3

60.0%

0.000

1

1.000

1.226

0.199–7.550

0.826

1.271

0.178–9.097

0.811

Others

1

33.3%

2

66.7%

0.000

1

1.000

1.639

0.145–18.460

0.689

2.577

0.225–29.471

0.446

At least one bidirectional comorbidity

17

30.9%

38

69.1%

6.680

1

0.010*

2.473

1.235–4.954

0.011*

2.162

1.037–4.506

0.040*

Number of bidirectional comorbidities

 0

51

52.0%

47

48.0.%

Fisher’s exact test

0.026*

1.713

1.139–2.577

0.010*

1.578

1.034–2.408

0.034*

 1

12

42.9%

16

57.1%

 2

4

18.2%

18

81.8%

 3

2

33.3%

4

66.7%

At least one causal comorbidity

32

39.50%

49

60.50%

1.94

1

0.164

1.574

0.830–2.983

0.165

1.265

0.632–2.532

0.506

Number of causal comorbidities

 0

37

50.70%

36

49.30%

Fisher’s exact test

0.125

1.457

0.780–2.721

0.237

1.157

0.588–2.278

0.673

 1

31

38.80%

49

61.30%

 2

1

100.00%

0

0.00%

At least one other comorbidity

36

49.40%

53

59.60%

1.63

1

0.203

1.518

0.797–2.893

0.204

1.580

0.798–3.164

0.188

Number of other comorbidities

 0

33

50.80%

32

49.20%

2.25

3

0.522

1.254

0.892–1.761

0.192

1.293

0.900–1.857

0.164

 1

21

41.20%

30

58.80%

 2

11

44.00%

14

56.00%

 3 + 

4

30.80%

9

69.20%

  1. *. P < 0.05; **. P < 0.01