Fig. 6

Role of glutamate transporters at glutamatergic synapases. The glutamate transportation includes synaptic release, extrasynaptically by exocytosis and the release of cystine-glutamate antiporter.To terminate the action of glutamate and maintain its extracellular concentration below excitotoxic levels, Na + -dependent high affinity glutamate transporters (EAATs)located on the plasma membrane of neurons and glial cells rapidly remove glutamate from the extracellular space. Gln Glutamine, Glu Glutamate, VGlut Vesicular glutamate transporter