Fig. 5
From: Successful medical treatment of west syndrome with a KCNA2 variant: a case report
Protein expression and structure prediction. The mutation occurs in the cytoplasmic N-terminus which is important for tetramerization. Interactions between the different subunits modulate the gating characteristics. The mutation leads to a change in the polarity of the amino acid at the position, which may lead to changes in gating characteristics and ion channel transport efficiency, but the protein function may not be completely lost