Managing reproductive problems in women with epilepsy of childbearing age

Acta Epileptologica

Table 3 Seizure occurrence rates in different studies

Study	Number of pregnancies	Study method	Center	Seizure rate/ ASM use								SDD	SE
Study	Number of pregnancies	Study method	Center	Total	LTG	VPA	CBZ	PB	PHT	LEV	OXC	SDD	SE
EURAP 2006 [78]	1956	Prospective registry	Multi (> 30)	41.60%	43.30%	23.80%	34.30%	29.00%	31.80%		58.50%	3.50%	1.80%
EURAP 2013 [72]	3784	Prospective registry	Multi (> 30)	33.40%	41.80%	25.00%	32.70%	26.60%				2.60%	0.56%
Thomas 2009 [79]	643	Prospective registry	Single	53.00%	44.40%	49.00%	56.70%	60.00%	66.70%			1.59%	0.47%
Vajda 2014 [73]	1111	Prospective registry	Multi (3)	–	51.30%	27.00%	37.80%			31.70%		–	–
Sabers 2009 [80]	42	Prospective registry	Single	46.00%	46.00%							–	–
Thomas 2012 [77]	1297	Prospective registry	Single	52.20%	CBZ PB PHT VPA CLB CLZ LTG LEV OXC PRM TPM							–	–
Cagnetti 2014 [81]	274	Prospective registry	Single	65.30%	CBZ LEV LTG OXC PB VPA							–	–
He 2017 [60]	155	Prospective registry	Single	67.10%	LEV VPA LTG CBZ OXC PHT TPM							9.68%	5.16%
Abe 2014 [82]	132	Retrospective	Multi (2)	27.30%	PB CBZ VPA CLZ CLB PRM DZP,ZNS							–	–
Reisinger 2013 [83]	115	Retrospective	Single	21.20%	LTG LEV CBZ TPM OXC PHT VPA ZNS ESM							–	–
Tomson 1994 [84]	89	Prospective registry	Single	45.00%	CBZ PHT CLZ PB PRM VPA ESM							–	–

ASM Antiseizure medication, CBZ Carbamazepine, CLB Clobazam, CLZ Clonazepam, DZP Diazepam, ESM Ethosuximide, LTG Lamotrigine, LEV Levetiracetam, OCB Oxcarbazepine, PB Phenobarbitone, PHT Phenytoin, PRM Primidone, SDD Seizure during delivery, SE Status epilepsy, TPM Topiramate, VPA Valproate, ZNS Zonisamide

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