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Table 3 Seizure occurrence rates in different studies

From: Managing reproductive problems in women with epilepsy of childbearing age

Study Number of pregnancies Study method Center Seizure rate/ ASM use SDD SE
Total LTG VPA CBZ PB PHT LEV OXC
EURAP 2006 [78] 1956 Prospective registry Multi (> 30) 41.60% 43.30% 23.80% 34.30% 29.00% 31.80%   58.50% 3.50% 1.80%
EURAP 2013 [72] 3784 Prospective registry Multi (> 30) 33.40% 41.80% 25.00% 32.70% 26.60%     2.60% 0.56%
Thomas 2009 [79] 643 Prospective registry Single 53.00% 44.40% 49.00% 56.70% 60.00% 66.70%    1.59% 0.47%
Vajda 2014 [73] 1111 Prospective registry Multi (3) 51.30% 27.00% 37.80%    31.70%  
Sabers 2009 [80] 42 Prospective registry Single 46.00% 46.00%       
Thomas 2012 [77] 1297 Prospective registry Single 52.20% CBZ PB PHT VPA CLB CLZ LTG LEV OXC PRM TPM
Cagnetti 2014 [81] 274 Prospective registry Single 65.30% CBZ LEV LTG OXC PB VPA
He 2017 [60] 155 Prospective registry Single 67.10% LEV VPA LTG CBZ OXC PHT TPM 9.68% 5.16%
Abe 2014 [82] 132 Retrospective Multi (2) 27.30% PB CBZ VPA CLZ CLB PRM DZP,ZNS
Reisinger 2013 [83] 115 Retrospective Single 21.20% LTG LEV CBZ TPM OXC PHT VPA ZNS ESM
Tomson 1994 [84] 89 Prospective registry Single 45.00% CBZ PHT CLZ PB PRM VPA ESM
  1. ASM Antiseizure medication, CBZ Carbamazepine, CLB Clobazam, CLZ Clonazepam, DZP Diazepam, ESM Ethosuximide, LTG Lamotrigine, LEV Levetiracetam, OCB Oxcarbazepine, PB Phenobarbitone, PHT Phenytoin, PRM Primidone, SDD Seizure during delivery, SE Status epilepsy, TPM Topiramate, VPA Valproate, ZNS Zonisamide