Skip to main content

Table 3 Seizure occurrence rates in different studies

From: Managing reproductive problems in women with epilepsy of childbearing age

Study

Number of pregnancies

Study method

Center

Seizure rate/ ASM use

SDD

SE

Total

LTG

VPA

CBZ

PB

PHT

LEV

OXC

EURAP 2006 [78]

1956

Prospective registry

Multi (> 30)

41.60%

43.30%

23.80%

34.30%

29.00%

31.80%

 

58.50%

3.50%

1.80%

EURAP 2013 [72]

3784

Prospective registry

Multi (> 30)

33.40%

41.80%

25.00%

32.70%

26.60%

   

2.60%

0.56%

Thomas 2009 [79]

643

Prospective registry

Single

53.00%

44.40%

49.00%

56.70%

60.00%

66.70%

  

1.59%

0.47%

Vajda 2014 [73]

1111

Prospective registry

Multi (3)

51.30%

27.00%

37.80%

  

31.70%

 

Sabers 2009 [80]

42

Prospective registry

Single

46.00%

46.00%

      

Thomas 2012 [77]

1297

Prospective registry

Single

52.20%

CBZ PB PHT VPA CLB CLZ LTG LEV OXC PRM TPM

Cagnetti 2014 [81]

274

Prospective registry

Single

65.30%

CBZ LEV LTG OXC PB VPA

He 2017 [60]

155

Prospective registry

Single

67.10%

LEV VPA LTG CBZ OXC PHT TPM

9.68%

5.16%

Abe 2014 [82]

132

Retrospective

Multi (2)

27.30%

PB CBZ VPA CLZ CLB PRM DZP,ZNS

Reisinger 2013 [83]

115

Retrospective

Single

21.20%

LTG LEV CBZ TPM OXC PHT VPA ZNS ESM

Tomson 1994 [84]

89

Prospective registry

Single

45.00%

CBZ PHT CLZ PB PRM VPA ESM

  1. ASM Antiseizure medication, CBZ Carbamazepine, CLB Clobazam, CLZ Clonazepam, DZP Diazepam, ESM Ethosuximide, LTG Lamotrigine, LEV Levetiracetam, OCB Oxcarbazepine, PB Phenobarbitone, PHT Phenytoin, PRM Primidone, SDD Seizure during delivery, SE Status epilepsy, TPM Topiramate, VPA Valproate, ZNS Zonisamide