Fig. 4

Effect of OSI-906 treatment on blood glucose before and after the seizures. (a) Blood glucose level did not significantly change at 1 h after the first OSI-906 gavage, compared with the control group (P > 0.05). (b&c) OSI-906 at 75 mg/kg significantly increased the blood glucose at fasting or 1 h after gavage on day 3. P = 0.0024 and 0.0002, respectively, vs the control, one-way ANOVA. (d) In the 75 mg/kg OSI-906 group, blood glucose levels were higher after the seizure compared with the control group. Data are shown as mean ± SEM. **P < 0.01, ***P < 0.001, ****P < 0.0001 (n = 5)