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Fig. 3 | Acta Epileptologica

Fig. 3

From: Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model

Fig. 3

Effects of OSI-906 on epileptic discharge in acute epileptic seizures. (a) Effects of OSI-906 on hippocampal electrical activity (the X-axis is 60 min and the Y-axis is ± 1.0 millivolts). (b) Corresponding power spectrograms of each group. (c-e) 50 mg/kg OSI-906 shortened the latency of epileptic discharge, and reduced the duration of epileptic discharge and the mean energy density value of brain electrical activity. Data are shown as mean ± SEM. *P < 0.05 and **P < 0.01 compared to the control group; n = 5 each group

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Acta Epileptologica

ISSN: 2524-4434

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