Table 1 Sample characteristics of studies comparing TLE patients versus HC
References | Sample characteristics Group size [mean age ± SD; Male:Female] | Social cognition: subfunction |
|---|---|---|
Ahs et al., 2014 [82] | lMTLE = 9 [44.8 ± 12.5; 2:7] | ER |
rMTLE = 8 [47.7 ± 9.4; 4:4] | ||
HC = 19 [46.1 ± 14; 9:10] | ||
Amlerova et al., 2014 [58] | lpreTL = 24 [33 ± 10; 12:12] | ER, ToM |
lpostTL = 13 [33 ± 7; 6:7] | ||
rpreTL = 22 [41 ± 11; 14:8] | ||
rpostTL = 15 [35 ± 8; 13:2] | ||
HC = 20 [33 ± 13; 6:14] | ||
Anderson et al., 2000 [83] | lTL = 11 [32 ± 8; 3:8] | ER |
rTL = 12 [38 ± 8; 4:8] | ||
HC = 23 [38 ± 8; 7:16] | ||
Arani et al., 2020 [84] | TLE = 60 [n.a. ± n.a.; n.a.] (age range: 20–50 years) | ER |
HC = 60 [n.a. ± n.a.; n.a.] | ||
Bala et al., 2018 [91] | ATL = 19 [35.94 ± 6.85; 10:9] | ToM |
MTLE = 21 [33.09 ± 11.41; 9:12] | ||
HC = 20 [30.23 ± 11.49; 10:10] | ||
Batut et al., 2006 [85] | lMTLE = 6 [37 ± 12; n.a.] | ER |
rMTLE = 6 [34 ± 11; n.a.] | ||
HC = 15 [n.a. ± n.a.; 6:9] | ||
Bauer et al., 2019 [85] | TLE = 17 [38.2 ± 14.8; 9:8] | ER, ToM |
HC = 51 [36.8 ± 10.9; 25:26] | ||
Benuzzi et al., 2004 [86] | lMTLE = 5 [30.4 ± 7.2; 3:2] | ER |
rMTLE = 8 [35.7 ± 7.2; 4:4] | ||
HC = 14 [n.a. ± n.a.; 7:7] (age range 21–27 years) | ||
Bonora et al., 2011 [59] | MTLE = 41 [48.05 ± 11.50; 17:24] | ER |
HC = 50 [34.9 ± 9.18; 20/30] | ||
Boucher et al., 2015 [60] | ATL = 15 [38.7 ± 10.3; 7:8] | ER, ToM |
IR = 15 [37.6 ± 8.6; 6:9] | ||
HC = 20 [36.1 ± 10.2; 10:10] | ||
Brierley et al., 2004 [61] | ATL = 28 [37.4 ± n.a.; 12:16] | ER |
HC = 32 [n.a.] | ||
*Broicher et al., 2012a [18] | MTLE = 28 [34.4313.25; 12:16] | ER, ToM |
HC = 29 [33.69 ± 10.94; 13:16] | ||
Broicher et al., 2012b [97] | MTLE = 28 [37.43 ± 12.60; 11:17] | ToM |
HC = 18 [31.22 ± 5.81; 6:12] | ||
Carvajal et al., 2009 [62] | lTL = 20 [35.4 ± 9.6; 10:10] | ER |
rTL = 23 [35 ± 12.1; 10:13] | ||
HC = 43 [53.7 ± 14.9; 20:23] | ||
Cohn et al., 2015 [63] | lTLE = 24 [38.9 ± 11.9; 13:11] | ER, ToM |
rTLE = 26 [38 ± 13.7; 14:12] | ||
lATL = 18 [42.5 ± 12.9; 11:7] | ||
rATL = 19 [38.9 ± 9.6; 7:12] | ||
HC = 15 [38.3 ± 8.6; 5:10] | ||
Glogau et al., 2004 [64] | MTLE = 28 [37.43 ± 12.6; 11:17] | ER |
HC = 18 [31.22 ± 5.81; 6:12] | ||
Giovagnoli et al., 2009 [92] | TLE = 21 [39.67 ± 14.41, 11:10] | ToM |
HC = 21 [41.81 ± 16.7; 8:13] | ||
*Giovagnoli et al., 2011 [101] | lTLE = 62 [35.96 ± 11.64; 24:38] | ToM |
rTLE = 47 [38.33 ± 10.64; 20:27] | ||
HC = 69 [52.03 ± 17.04; 29:40] | ||
*Giovagnoli et al., 2013 [42] | TLE = 54 [37.80 ± 9.20; 26:28] | ToM |
HC = 42 [n.a. ± 12.61; 18:24] (age range 40–64) | ||
Giovagnoli et al., 2016 [98] | eTLE = 31 [31.87 ± 9.4; 19:12] | ToM |
lTLE = 54 [34.91 ± 10.23; 33:21] | ||
HC = 40 [36.05 ± 9.64; 29:11] | ||
Giovagnoli et al., 2020 [99] | TLE = 50 [40.8 ± 12.98; 19:31] | ToM |
HC = 50 [39.20 ± 13.32; 21:29] | ||
Gomez-Ibanez et al., 2014 [65] | MTLE = 19 [41.9 ± 10.6; 8:11] | ER |
HC = 23 [37.3 ± 10.7; 7:16] | ||
Gosselin et al., 2011 [66] | TL = 14 [42.1 ± n.a.; 8:8] | ER |
HC = 16 [n.a.] | ||
Hennion et al., 2015a [100] | TLE = 50 [42.4 ± 11.82; 23:27] | ToM |
HC = 50 [42.81 ± 12.46; 23:27] | ||
Hennion et al., 2015b [67] | TLE = 50 [42.4 ± 11.82; 23:27] | ER |
HC = 50 [42.81 ± 12.46; 23:27] | ||
Hennion et al., 2016 [93] | rMTLE = 12 [42.09 ± 12.62; 8:4] | ToM |
lMTLE = 13 [42.54 ± 9.6; 6:7] | ||
HC = 25 [42.5 ± 12.3; 14:11] | ||
Hlobil et al., 2008 [68] | r/preATL = 24 [28.8 ± 11.4; 10:14] | ER |
l/preATL = 12 [29.5 ± 7.4; 3:9] | ||
r/postATL = 21 [33.4 ± 10.5; 10:11] | ||
l/postATL = 19 [30.1 ± 11.7; 9:10] | ||
HC = 28 [31.1 ± 12.3; 17:11] | ||
Huang et al., 2020 [69] | MTLE-TLS = 20 [52.3 ± n.a.; 12:8] | ER |
HC = 12 [54.7 ± n.a.; 5:7] | ||
Li et al., 2013 [94] | lTLE = 11 [37.55 ± 14.7; 5:6] | ToM |
rTLE = 13 [43.31 ± 11.83; 8:5] | ||
bTLE = 7 [46.14 ± 13.07; 5:2] | ||
HC = 24 [37.75 ± 16.77; 13:11] | ||
McClelland et al., 2006 [75] | (l/e)ATL = 12 [30.3 ± n.a.; n.a.] | ER |
HC = 10 [30.4 ± n.a.; 5:5] | ||
Meletti et al., 2003 [41] | MTLE = 33 [36.1 ± 10.6; 13:20] | ER |
TLE = 30 [35.8 ± 10.7; 12:18] | ||
HC = 50 [34, n.a.; 18:32] | ||
Meletti et al., 2009 [70] | MTLE = 140 [38.6 ± 9.9; 63:77] | ER |
TLE = 36 [37.1 ± 11.6; 16:20] | ||
HC = 50 [34.9 ± 9.1; 20:30] | ||
Meletti et al., 2014 [71] | ATL = 42 [45.3 ± 11.3; 25:17] | ER |
HC = 39 [44 ± 11.5; 22:17] | ||
Okruszek et al., 2017 [95] | MTLE = 31 [30.9 ± 7.7; 14:17] | ToM |
HC = 47 [32.3 ± 9.1; 25:22] | ||
Palermo et al., 2010 [72] | lTL = 7 [46 ± 10; 1:6] | ER |
rTL = 8 [44.6 ± 6; 3:5] | ||
HC = 13 [43 ± 13; 7:6] | ||
*Realmuto et al., 2015 [88] | TLE = 21 [37 ± 12.5; 8:13] | ER, ToM |
HC = 21 [31.95 ± 11.54; 12:9] | ||
*Reynders et al., 2005 [89] | IF-TLE = 13 [39.23 ± 9.72; 8:5] | ER |
TLE = 14 [39.57 ± 12.36; 7:7] | ||
HC = 12 [39.92 ± 12.87; 6:6] | ||
Rotshtein et al., 2010 [76] | aMTLE = 7 [34.5 ± n.a.; 3:4] | ER |
MTLE = 10 [37.7 ± n.a.; 5:5] | ||
HC = 13 [31.6 ± n.a.; 6:7] | ||
*Schacher et al., 2006 [43] | MTLE = 27 [36.5 ± 10.7; 13:14] | Schacher |
HC = 12 [33.8 ± 12.4; 7:5] | ||
Sedda et al., 2013 [73] | rTLE = 24 [35.33 ± 11.06; 14:10] | ER |
lTLE = 32 [38.31 ± 12.11; 18:14] | ||
HC = 54 [35.7 ± 11.35; 23:31] | ||
Shaw et al., 2007 [74] | rATL = 10 [41 ± 9; 5:5] | ER, ToM |
lATL = 9 [33 ± 11; 3:6] | ||
HC = 19 [33 ± 11; 6:13] | ||
Szaflarski et al., 2014 [77] | lTLE = 34 [41 ± 12; 7:27] | ER |
HC = 30 [39 ± 11; 8:22] | ||
Szaflarski et al., 2018 [78] | TLE = 12 [40 ± 12; 2:10] | ER |
HC = 24 [36 ± 11; 4:20] | ||
Tanaka et al., 2013 [79] | MTLE = 63 [41.5 ± n.a.; 32:31] | ER |
postTL = 25 [43 ± n.a.; 9:16] | ||
HC = 32 [33 ± n.a.; 7:25] | ||
Walpole et al., 2008 [80] | TLE = 16 [45.31 ± 11.81; 9:7] | ER |
HC = 14 [43.86 ± 10.92; 6:8] | ||
Wang et al., 2015 [96] | TLE = 67 [32.19 ± 10.22; 36:31] | ToM |
HC = 30 [33.4 ± 9.57; 16:14] | ||
Wendling et al., 2015 [81] | SAH = 27 [41.38 ± 8.3; 10:17] | ER |
ATL = 33 [40.12 ± 9.12; 17:16] | ||
HC = 30 [40.58 ± 4.78; 15:15] |