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Table 4 Adverse events in patients with infantile spasms at different time points of follow-up

From: A multicenter retrospective cohort study of ketogenic diet therapy in 481 children with infantile spasms

Adverse events, n (%) 1 month 3 months 6 months 12 months
Gastrointestinal disdurbance* 41 (9.1) 24 (6.0) 8 (3.0) 2 (1.3)
Constipation 22 (4.9) 13 (3.3) 7 (2.6) 3 (1.9)
Fever 10 (2.2) 9 (2.3) 1 (0.4) 1 (0.6)
Cold 6 (0.66) 2 (0.5) 3 (1.1) 0
Lack of energy or mental health 5 (1.1) 0 0 0
Cough 3 (0.7) 4 (1.0) 0 0
Anorexia * 4 (0.9) 10 (2.5) 13 (4.9) 4 (2.5)
Pneumonia 4 (0.9) 9 (2.3) 6 (2.2) 0
Symptomatic hypoglycemia 1 (0.2) 3 (0.8) 1 (0.4) 0
Enteritis 1 (0.2) 0 0 0
Allergy 1 (0.2) 1 (0.3) 0 0
High triglycerides
or cholesterol
2 (0.4) 4 (1.0) 2 (0.8) 0
Kidney stones 0 0 0 1 (0.6)
Low bone mineral density 1 (0.2) 1 (0.3) 2 (0.8) 0
Hypoproteinemia* 0 6 (1.5) 2 (0.8) 0
Continuation of KD (n) 452 397 268 159
Total (%) 101/452 (22.3) 86/397 (21.7) 45/268 (16.8) 11/159 (6.9)