From: Managing reproductive problems in women with epilepsy of childbearing age
Study | Study method | Center | Number of pregnancies | SF increased | SF decreased | SF unchanged | ASM use | Reference |
---|---|---|---|---|---|---|---|---|
EURAP 2013 [72] | Prospective | Multi (> 30) | 3735 | 15.80% | 12.00% | 70.50% | CBZ LTG VPA PB | First pregnancy trimester |
EURAP 2006 [78] | Prospective | Multi (> 30) | 1956 | 17.30% | 15.90% | 63.60% | CBZ OXC LTG VPA PHT PB | First pregnancy trimester |
Cagnetti 2014 [81] | Prospective | Single | 274 | 23.40% | 17.50% | 59.10% | CBZ LEV LTG OXC PB VPA | Nine months before prepregnancy |
Bardy 1987 [85] | Prospective | Single | 154 | 32.00% | 14.00% | 54.00% | PHT CBZ CZP PRM ESM SLT PB VPA | Prepregnancy |
Reisinger 2013 [83] | Retrospective | Single | 115 | 38.30% | 17.40% | 44.30% | LTG LEV CBZ TPM OXC | Twelve months before pregnancy |
Otani 1985 [86] | Prospective | Single | 110 | 16.00% | 4.00% | 80.00% | PHT PB PRM CBZ VPA | Ten months before pregnancy |
Tomson 1994 [84] | Prospective | Single | 89 | 15.00% | 24.00% | 61.00% | CBZ PHT CLZ ESM PB PRM VPA | One month before pregnancy |
Gjerde 1988 [87] | Prospective | Single | 78 | 17.00% | 17.00% | 67.00% | CBZ PHT PB VPA PRM CLZ CLB | Prepregnancy |
Sabers 2009 [80] | Prospective | Single | 42 | 19.00% | 10.00% | 71.00% | LTG | Prepregnancy |
Hoeritzauer 2012 [88] | Prospective | Single | 39 | 30.80% | 17.90% | 51.30% | LEV | Prepregnancy |
Pennell 2008 [89] | Prospective | Single | 36 | 39.00% | 33.00% | 28.00% | LTG | Prepregnancy |
La Neve 2015 [75] | Prospective case control | Single | 36 (72 control) | 19% (11%) | 8% (7%) | 72% (82%) | CBZ VPA | Prepregnancy |