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Table 1 Years of introduction in the market of currently available antiseizure medications. For all drugs, year of introduction refers to either Europe or the United States of America. The table does not include a number of drugs approved before 1970, but rarely used today

From: The pharmacological treatment of epilepsy: recent advances and future perspectives

1900–1950 1951–1985 1986–2000 2001–2015 2015–2021
Phenobarbital
Phenytoin
Carbamazepine
Clobazam
Clonazepam
Diazepam
Ethosuximide
Midazolam
Primidone
Valproic acid
Felbamate
Fosphenytoin
Gabapentin
Lamotrigine
Levetiracetam
Lorazepam
Oxcarbazepine
Tiagabine
Topiramate
Vigabatrin
Zonisamide
Eslicarbazepine acetate
Lacosamide
Perampanel
Pregabalin
Rufinamide
Stiripentol
Brivaracetam
Cannabidiol
Cenobamate
Everolimus
Fenfluramine