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Table 2 Effects of OSI-906 on blood glucose (n = 5)

From: Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model

Groups Blood glucose 1 h after the first OSI-906 (mmol/L) Blood glucose before gavage on day 3 (mmol/L) Blood glucose1 h after gavage on day 3 (mmol/L) Blood glucose 1 h after SE (mmol/L)
vehicle 5.94 ± 0.31 6.02 ± 0.48 6.26 ± 0.79 15.60 ± 1.09
OSI-906 25 mg/kg 6.24 ± 0.49 6.56 ± 0.54 7.10 ± 0.84 16.78 ± 1.18
OSI-906 50 mg/kg 6.52 ± 0.58 7.22 ± 1.20 8.44 ± 2.18 17.04 ± 1.44
OSI-906 75 mg/kg 6.84 ± 0.90 8.12 ± 2.10** 11.18 ± 4.92*** 33.33****
  1. **P < 0.01, ***P < 0.001, and ****P < 0.0001 vs the vehicle control group