Groups | Blood glucose 1 h after the first OSI-906 (mmol/L) | Blood glucose before gavage on day 3 (mmol/L) | Blood glucose1 h after gavage on day 3 (mmol/L) | Blood glucose 1 h after SE (mmol/L) |
---|---|---|---|---|
vehicle | 5.94 ± 0.31 | 6.02 ± 0.48 | 6.26 ± 0.79 | 15.60 ± 1.09 |
OSI-906 25 mg/kg | 6.24 ± 0.49 | 6.56 ± 0.54 | 7.10 ± 0.84 | 16.78 ± 1.18 |
OSI-906 50 mg/kg | 6.52 ± 0.58 | 7.22 ± 1.20 | 8.44 ± 2.18 | 17.04 ± 1.44 |
OSI-906 75 mg/kg | 6.84 ± 0.90 | 8.12 ± 2.10** | 11.18 ± 4.92*** | ≧33.33**** |