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Table 2 Effects of OSI-906 on blood glucose (n = 5)

From: Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model

Groups

Blood glucose 1 h after the first OSI-906 (mmol/L)

Blood glucose before gavage on day 3 (mmol/L)

Blood glucose1 h after gavage on day 3 (mmol/L)

Blood glucose 1 h after SE (mmol/L)

vehicle

5.94 ± 0.31

6.02 ± 0.48

6.26 ± 0.79

15.60 ± 1.09

OSI-906 25 mg/kg

6.24 ± 0.49

6.56 ± 0.54

7.10 ± 0.84

16.78 ± 1.18

OSI-906 50 mg/kg

6.52 ± 0.58

7.22 ± 1.20

8.44 ± 2.18

17.04 ± 1.44

OSI-906 75 mg/kg

6.84 ± 0.90

8.12 ± 2.10**

11.18 ± 4.92***

33.33****

  1. **P < 0.01, ***P < 0.001, and ****P < 0.0001 vs the vehicle control group