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Table 1 Effect of OSI-906 on acute epileptic seizures (n = 13)

From: Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model

Group Latency of seizure (min) Seizure onset rate at
the first dose
Cumulative seizure rate Mortality
Vehicle 28.55 ± 2.76 7/13 (53.85%) 11/13 (84.62%) 4/13 (30.77%)
OSI-906 25 31.30 ± 4.01 6/13 (46.15%) 10/13 (76.92%) 3/13 (23.08%)
OSI-906 50 41.33 ± 12.79* 1/13 (7.69%)* 6/13 (46.15%) 0/13 (0%)
OSI-906 75 14.46 ± 14.08** 13/13 (100%)* 13/13 (100%)* 13/13 (100%)**
  1. Note: The dosing unit of OSI-906 is mg/kg. Compared with the vehicle group, *P < 0.05 and **P < 0.01