Fig. 7

Effects of OSI-906 on IR, IGF-1R and AKT signaling. (a) The representative bands of western blotting. (b-d) The pIR/IR, pIGF-1R/IGF-1R, and p-Akt/Akt ratios were significantly elevated at 24 h after pilocarpine-induced seizures, compared with those in the vehicle group. Compared to those in the seizure group, these ratios were markedly reduced in the 50 mg/kg OSI-906 group. Data are shown as mean ± SEM. n = 5, ANOVA,**P < 0.01, ***P < 0.001, ^#P < 0.05, ^###P < 0.001