Fig. 5
OSI-906 decreased the glucose uptake 1 h after seizures. (a) 18F-FDG micro-PET/CT quantification of glucose metabolism in vivo. (b) Compared with the normal control group, the average whole-brain SUV value was significantly increased 1 h after pilocarpine-induced epileptic seizures. Treatment with 50 mg/kg of OSI-906 significantly reduced the value of glucose uptake in the brain (n = 5). Data are shown as mean ± SEM. **P < 0.01, #P < 0.05