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Fig. 2 | Acta Epileptologica

Fig. 2

From: Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model

Fig. 2

Effects of OSI-906 on acute epileptic seizures. (a) 50 mg/kg OSI-906 extended the seizure latency. (b) 50 mg/kg OSI-906 significantly reduced Racine score, but 75 mg/kg OSI-906 aggravated the severity of seizures. (c&d) First-dose and cumulative stage 4–5 seizure rates. (e) Effects of OSI-906 on mortality in acute rats. Bars represent mean ± SEM (n = 13 for each group). *P < 0.05 and **P < 0.01 compared to the control group

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Acta Epileptologica

ISSN: 2524-4434

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