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Table. 1 Changes of ASM and seizure frequency during different trimesters

From: Seizure frequency and obstetric complications at advanced maternal age: a preliminary observational study in women with epilepsy

NO. ASM before pregnancy Seizure frequency before pregnancy ASM changes in the 1st trimester ASM changes in the 2nd trimester ASM changes in the 3rd trimester Seizure frequency change in the 1st trimester Seizure frequency change in the 2nd trimester Seizure frequency change in the 3rd trimester
1 VPA Yearly Stop ASM   VPA resumed   Increased Increased
2 PHT Monthly Stop ASM   PHT resumed Increased Increased Increased
3 CBZ More than 1 year       
4 LEV Monthly Stop ASM LEV resumed   Increased Increased  
5   More than 1 year       
6 OXC, LEV Monthly     Decreased Decreased  
7   More than 1 year       
8   More than 1 year       
9 LEV Monthly Stop ASM      Decreased
10 TPM More than 1 year    TPM dose decrease    
11 CBZ, LEV Daily      Increased Decreased
12 CBZ, LEV Daily      Increased Decreased
13   More than 1 year       Increased
14 LTG, LEV Monthly LTG dose increase LEV dose increase LTG dose increase Increased Increased Increased
15 TPM, PHT Monthly   PHT → LTG TPM → LEV    
  1. ASM anti-seizure medications, VPA valproate, PHT phenytoin, CBZ carbamazepine, LEV levetiracetam, OXC oxcarbazepine, TPM topiramate, LTG lamotrigine