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Table. 1 Changes of ASM and seizure frequency during different trimesters

From: Seizure frequency and obstetric complications at advanced maternal age: a preliminary observational study in women with epilepsy

NO.

ASM before pregnancy

Seizure frequency before pregnancy

ASM changes in the 1st trimester

ASM changes in the 2nd trimester

ASM changes in the 3rd trimester

Seizure frequency change in the 1st trimester

Seizure frequency change in the 2nd trimester

Seizure frequency change in the 3rd trimester

1

VPA

Yearly

Stop ASM

 

VPA resumed

 

Increased

Increased

2

PHT

Monthly

Stop ASM

 

PHT resumed

Increased

Increased

Increased

3

CBZ

More than 1 year

      

4

LEV

Monthly

Stop ASM

LEV resumed

 

Increased

Increased

 

5

 

More than 1 year

      

6

OXC, LEV

Monthly

   

Decreased

Decreased

 

7

 

More than 1 year

      

8

 

More than 1 year

      

9

LEV

Monthly

Stop ASM

    

Decreased

10

TPM

More than 1 year

  

TPM dose decrease

   

11

CBZ, LEV

Daily

    

Increased

Decreased

12

CBZ, LEV

Daily

    

Increased

Decreased

13

 

More than 1 year

     

Increased

14

LTG, LEV

Monthly

LTG dose increase

LEV dose increase

LTG dose increase

Increased

Increased

Increased

15

TPM, PHT

Monthly

 

PHT → LTG

TPM → LEV

   
  1. ASM anti-seizure medications, VPA valproate, PHT phenytoin, CBZ carbamazepine, LEV levetiracetam, OXC oxcarbazepine, TPM topiramate, LTG lamotrigine