|
NO.
|
ASM before pregnancy
|
Seizure frequency before pregnancy
|
ASM changes in the 1st trimester
|
ASM changes in the 2nd trimester
|
ASM changes in the 3rd trimester
|
Seizure frequency change in the 1st trimester
|
Seizure frequency change in the 2nd trimester
|
Seizure frequency change in the 3rd trimester
|
|---|
|
1
|
VPA
|
Yearly
|
Stop ASM
| |
VPA resumed
| |
Increased
|
Increased
|
|
2
|
PHT
|
Monthly
|
Stop ASM
| |
PHT resumed
|
Increased
|
Increased
|
Increased
|
|
3
|
CBZ
|
More than 1 year
| | | | | | |
|
4
|
LEV
|
Monthly
|
Stop ASM
|
LEV resumed
| |
Increased
|
Increased
| |
|
5
| |
More than 1 year
| | | | | | |
|
6
|
OXC, LEV
|
Monthly
| | | |
Decreased
|
Decreased
| |
|
7
| |
More than 1 year
| | | | | | |
|
8
| |
More than 1 year
| | | | | | |
|
9
|
LEV
|
Monthly
|
Stop ASM
| | | | |
Decreased
|
|
10
|
TPM
|
More than 1 year
| | |
TPM dose decrease
| | | |
|
11
|
CBZ, LEV
|
Daily
| | | | |
Increased
|
Decreased
|
|
12
|
CBZ, LEV
|
Daily
| | | | |
Increased
|
Decreased
|
|
13
| |
More than 1 year
| | | | | |
Increased
|
|
14
|
LTG, LEV
|
Monthly
|
LTG dose increase
|
LEV dose increase
|
LTG dose increase
|
Increased
|
Increased
|
Increased
|
|
15
|
TPM, PHT
|
Monthly
| |
PHT → LTG
|
TPM → LEV
| | | |
- ASM anti-seizure medications, VPA valproate, PHT phenytoin, CBZ carbamazepine, LEV levetiracetam, OXC oxcarbazepine, TPM topiramate, LTG lamotrigine
