Table 1 Review of HHV-6 PCR-studies in patients with MTLE
From: Temporal lobe epilepsy associated with human herpes virus 6
Publication | MTLE (n) | HHV-6+ n (%) | History of febrile seizures y(%) | Type of seizures (n) | Seizure onset age years (median/range) | Age at time of surgery years (median/range) | MRI+ n(%) | Other past history (n) | Pathology (n) | Localization of HHV-6 (n) |
|---|---|---|---|---|---|---|---|---|---|---|
Uesugi | 15 | 6 (40%) | 2 (13.4%) | CPS(15) | 11.1/2–21 | 24.9/− | – | Exanthema subitum status(2) | AHS (12); Gliosis (9); Hippocampal gliosis (2): Inflammatory (2) | Hippocampus (3); lateral temporal lobe (2); both hippocampus and lateral temporal lobe (1) |
et al. (2000) [30] | ||||||||||
Donati | 8 | 4 (50%) | 4 (50%) | – | 12.4/1–26 | 31.1/− | 8 (100%) | – | MTS (8) | Astrocytes;hippocampus |
et al. (2003) [31] | ||||||||||
Eeg-Olofsson | 36 | 7 (19.4%) | 11 (30.6%) | – | – | 18.9/− | – | – | Gliosis (19); Ganglioglioma (6); Cortical dysplasia, gliosis (4); Rasmussen’s encephalitis (3); Cortical dysplasia (2); Porencephaly (1) | – |
et al. (2004) [32] | ||||||||||
Fotheringham | 16 | 11 (69%) | 5 (31.3%) | – | 11.4/1–38 | 25.8/8.5–45 | 13 (81.3%) | – | MTS(13);Gliosis (2);Dysplasia, no tumour (1);Mild diffuse HF neuronal loss(1) | Astrocytes;hippocampus |
et al. (2007) [2] | ||||||||||
Karatas | 33 | 3 (9.1%) | 25 (75.8%) | CPS (16); CPS, SGTCS (8); CPS, SGTCS, SPS (3);CPS, SPS (4); SGTCS (2) | 10.5/1–27 | 27.2/17–40 | 33 (100%) | Head trauma (9); perinatal injury (5) | HS | Hippocampus |
et al. (2008) [25] | ||||||||||
Niehusmann | 38 | 8 (21.1%) | 6 (15.8%) | – | 13.4/− | 27.8/− | – | Encephalitis (21) | MTS; hippocampal gliosis | Astrocytes;hippocampus |
et al. (2010) [33] | ||||||||||
Li | 32 | 9 (28.1%) | 11 (34.4%) | – | 13.4/1–35 | 23.2/− | 26 (81.3%) | – | HS (32) | Astrocytes and microglia;hippocampal;temporal neocortex |
et al. (2011) [34] | ||||||||||
Esposito | 346 | 34 (9.8%) | 55 (15.9%) | – | 13.0 ± 11.0(SD) | 35.1 ± 14.2(SD) | – | Encephalitis/meningitis (52) | HS (287) | Astrocytes and neuron |
et al. (2015) [26] | ||||||||||
Kawamura | 75 | 24 (34.7%) | 30 (40%) | – | 12.0/1.0–40.0 | 16.0/2.0–50 | – | Head injury (6);CNS infection (4) | MTS (52); Swelling of amygdala (4); Hamartoma of amygdala (3) | Hippocampus (15); amygdala (10); mixed amygdala and uncus (7) |
et al. (2015) [13] | ||||||||||
Huang | 46 | 18 (39%) | 13 (28.3%) | CPS (26); SGS (20) | – | 26.3/14–57 | 38 (82.6%) | – | HS (43) | Astrocytes; hippocampus |
et al. (2015) [35] |