Association between GABRG2 rs211037 polymorphism and febrile seizures: a meta-analysis

Acta Epileptologica

Table 3 Stratified analysis of the association between GABRG2 rs211037 polymorphism and FS

Variable	n^a	TT + CT vs CC		TT vs CT + CC		TT vs CC		CT vs CC		T vs C
Variable	n^a	OR (95%CI)	P_het	OR (95%CI)	P_het	OR (95%CI)	P_het	OR (95%CI)	P_het	OR (95%CI)	P_het
Total	12	0.95 (0.64, 1.41)	< 0.001	0.82 (0.50, 1.32)	< 0.001	0.76 (0.39,1.46)	< 0.001	1.05 (0.76,1.44)	0.04	0.95 (0.69, 1.32)	< 0.001
Ethnicity
Asian	5	0.70 (0.48, 1.02)	0.65	0.63 (0.45, 0.88)	0.19	0.56 (0.36,0.87)	0.5	0.79 (0.53, 1.18)	0.57	0.73 (0.59, 0.90)	0.34
Caucasian	3	1.76 (0.97, 3.17)	0.03	1.36 (0.35, 5.27)	0.02	1.73 (0.34,8.78)	< 0.001	1.56 (1.14, 2.15)	0.27	1.57 (0.87, 2.83)	0.003
Healthy control
Yes	9	0.76 (0.51, 1.12)	0.03	0.59 (0.45, 0.77)	0.38	0.50 (0.35,0.71)	0.41	0.96 (0.75, 1.24)	0.13	0.79 (0.61, 1.02)	0.01
No	3	1.86 (0.78, 4.43)	0.02	1.52 (0.25, 9.11)	0.02	1.92 (0.22,16.68)	0.004	1.67 (1.07, 2.61)	0.2	1.66 (0.71, 3.88)	0.002
Matched controls
Yes	6	0.60 (0.43, 0.86)	0.2	0.56 (0.39, 0.80)	0.31	0.40 (0.25, 0.63)	0.41	0.71 (0.49, 1.04)	0.28	0.64 (0.52, 0.80)	0.23
No	6	1.35 (0.86, 2.11)	0.02	1.01 (0.43, 2.36)	< 0.001	1.16 (0.41, 3.22)	< 0.001	1.37 (1.05,1.78)	0.27	1.21 (0.77, 1.91)	< 0.001

CI confidence interval, OR odds ratio, Phet P value of Q test for heterogeneity test
^aNumber of datasets included in the meta-analysis

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