Fig. 5

Spine density and number of mushroom-type spines in epileptic rats. a Spines observed at 40× magnification in the CA3 region. Scale bar represents 5 μm. b Quantification of spines per μm of dendrites length. The amount of spines increased during the epileptogenesis, and then decreased after 10 times of SRS. c Quantification of mushroom spines. Data are presented as mean ± SEM. * P < 0.05, **P < 0.01 and ***P < 0.001