Table 1 Statistical prediction models for the response to AEDs treatment
Study | Study design | Prediction target | Development cohort | Final factors | Validation cohort | AUC | Stratified risks |
|---|---|---|---|---|---|---|---|
Boonluksiri et al. 2015 [16] | Retrospective | DRE in children | 308 cases in Hatyai Hospital in Thailand | Age onset, prior neurological deficits and abnormal EEG | No | 0.76 | low risk: < 6 points; moderate risk: 6–12 points; high risk: > 12 points |
Yang et al. 2019 [15] | Retrospective | DRE in adults | 132 cases at Henan Provincial People’s Hospital in China | EEG before AEDs, history of CNS infection, initial precipitating injuries, and more than one recurrence in the first 6 months | No | 0.89 | low risk: < 3 points; moderate risk: 3–5 points; high risk: > 5 points |
Latzer et al. 2019 [17] | Retrospective | DRE in children with cerebral palsy | 281 children with cerebral palsy at the Dana-Dwek Children’s Hospital | Low Apgar score at 5 min, neonatal seizures, focal-onset epilepsy and focal slowing on EEG | No | 0.68 | No |