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Table 3 Functional roles of the 5 hub genes

From: Effects of febrile seizures in mesial temporal lobe epilepsy with hippocampal sclerosis on gene expression using bioinformatical analysis

No. Gene symbol Full name Functions of encoded protein
1 SNAP25 Synaptosome Associated Protein 25 Participates in the synaptic function of specific neuronal systems.
2 SLC32A1 Solute Carrier Family 32 Member 1 Involved in the uptake of GABA and glycine into the synaptic vesicles.
3 SYN1 Synapsin I Functions in the regulation of neurotransmitter release.
4 GRIN1 Glutamate Ionotropic Receptor NMDA Type Subunit 1 A component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels.
5 GRIA1 Glutamate Ionotropic Receptor AMPA Type Subunit 1 An ionotropic glutamate receptor, which facilitates excitatory neurotransmitter transport at many synapses in the central nervous system.