Systemic evidence of acute seizure-associated elevation in serum neuronal injury biomarker in patients with temporal lobe epilepsy

Table 1 Demographic information for subjects with intractable focal epilepsy

Study ID	Age^a	Sex	Ethnicity	Primary diagnosis^b	Disease onset^c	Disease duration^d	MTS^e
E001	30–35	F	White Not Hispanic / Latino	Intractable focal epilepsy; temporal lobe epilepsy; prior history of L temporal lobectomy (2012)	8 YO	23 y	L MTS by pathology
E002	25–30	M	White Not Hispanic / Latino	Intractable focal epilepsy; temporal lobe epilepsy; history of febrile illness-associated encephalitis	25 YO	5 m	MRI evidence of bilateral MTS
E003	45–50	F	White Not Hispanic / Latino	Intractable focal epilepsy; temporal lobe epilepsy	17 YO	32 y	No evidence of MTS on MRI
E004	40–45	M	White Not Hispanic / Latino	Intractable focal epilepsy; temporal lobe epilepsy; remote history of prior R temporal lobectomy (2001); right parietal lobectomy (2016)	1 YO	41 y	R parietal lobe sclerosis and neuronal karyorrhexis by pathology
E005	30–35	F	White Not Hispanic / Latino	Intractable focal epilepsy; temporal lobe epilepsy; remote history of severe limbic encephalitis	24 YO	9 y	MRI evidence of bilateral MTS
E006	35–40	F	White Not Hispanic / Latino	Intractable focal epilepsy; temporal lobe epilepsy	14 YO	24 y	No evidence of MTS
E007	40–45	M	White Not Hispanic / Latino	Intractable focal epilepsy; temporal lobe epilepsy; prior history of R anterior temporal lobectomy (2008)	6 MO	29 y	R MTS by pathology

^aAge at time of enrollment (in years); range provided for anonymization
^bL left, R right
^cYO years old, MO months old
^dDisease duration at time of enrollment; y years, m months
^eMTS mesial temporal sclerosis; changes on MRI (hippocampal atropy and increased T2 signal) or pathological diagnosis

ISSN: 2524-4434