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Fig. 1 | Acta Epileptologica

Fig. 1

From: Systemic evidence of acute seizure-associated elevation in serum neuronal injury biomarker in patients with temporal lobe epilepsy

Fig. 1

Serum levels of NSE and S100β in epilepsy patients and healthy controls are not different when analyzed in aggregate. a Multiple serum samples were collected from 7 patients in the epilepsy monitoring unit (EMU) at different times (6 AM, 9 AM, noon, 3 PM, and 6 PM) during several days of monitoring; each sample is represented by one dot. NSE was measured in serum collected from 4 healthy control subjects in the clinical research unit (CRU) at 6 AM, 9 AM, noon, 3 PM, and 6 PM during 1 day to establish a reference range for samples collected under conditions identical to the EMU patients (blue bar shows mean ± 95% CI; each sample is represented by one dot). Data are not normally distributed (W = 0.6415, P < 0.001 by Shapiro-Wilk test). One-way ANOVA with Dunnett’s pairwise comparison to group CRU controls revealed that NSE levels were only signficantly elevated in 1 of the 7 EMU patients (# = P < 0.01; NS = not signficant). b The same EMU and CRU serum samples used for NSE were assessed for S100β (blue bar shows mean ± 95% CI for CRU controls). S100β levels were not elevated in any of the EMU patients and were, in fact, relatively lower in some patients

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